Pair Name	Zerumbone, Nimesulide
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Gene Regulation	Down-regulation	Expression	COX2	hsa4513
In Vivo Model	Acute colitis was induced by exposing female ICR mice to 5% DSS in drinking water for 1 week. One week prior to DSS administration, the experimental mice were fed ZER alone, nimesulide (NIM, a selective COX-2 inhibitor) alone, or both in combination (1000 ppm each) for a total of 2 weeks.
Result	Our results suggest that ZER is a novel food factor for mitigating experimental UC and that use of a combination of agents, with different modes of actions, may be an effective anti-inflammatory strategy.